Thibaut Courtois and Andreas Christensen are doubts for Chelsea.
Goalkeeper Courtois sustained a hamstring problem before the international break, meaning Willy Caballero could deputise, while centre-back Christensen has been struggling with fatigue.
Defender David Luiz (knee) is definitely out, along with midfielder Ross Barkley who is set to feature for the club’s under-23 side.
Tottenham boss Mauricio Pochettino will give Harry Kane every chance to prove his fitness.
Kane suffered ankle ligament damage three weeks ago and Pochettino said on Thursday that he cannot rule his striker out of the game at Stamford Bridge.
Harry Winks is definitely missing as he sees a specialist over his own ankle injury
Tottenham 2 Chelsea 0, Chelsea 2 Tottenham 1
Last five league matches
Chelsea L W L L W; Tottenham D W W W W
Eden Hazard (Chelsea) 15; Harry Kane (Tottenham) 35
Chelsea 13-10, Spurs 21-10, Draw 11-5
Referee: Andre Marriner (West Midlands)