Brentford found themselves a goal down on the stroke of half-time after a high-tempo first 45 minutes at Griffin Park.
After Ryan Fraser’s shot had clipped the inside of the post, the ball was worked back into the box and into the path of Kevin Bru, who tucked home.
Minutes earlier, Bees keeper David Button bravely denied Freddie Sears as Ipswich ended the first half the stronger of the two sides.
But Brentford had created the better chances overall, with Jota’s header brilliantly clawed away by Ipswich keeper Bartosz Bialkowski and Alan Judge’s free-kick curling just wide of the near post.
Marinus Dijkhuizen’s side showed some neat touches in attack, with Judge and Andy Gogia lively, but they came up against a robust Ipswich defence.
Hull City target Andre Gray is only among the Brentford substitutes for the Championship opener.
As well as Gogia, Philipp Hofmann and Konstantin Kerschbaumer are also making their Bees debuts.