Maxime Colin makes his first start for Brentford in the only change from the line-up that lost to Burnley last weekend.
The new signing from Anderlecht replaces Alan McCormack, who drops to the bench.
Sam Saunders returns to the Bees squad after recovering from injury and could make his first appearance for Brentford since February.
Reading also make one change, with Nick Blackman replacing Aaron Tshibola from the side that drew 0-0 with MK Dons.
Peruvian midfielder Paulo Hurtado is included among the substitutes for the first time.
Subs: Bonham, McCormack, Barbet, O’Connell, Saunders, Udumaga, Clarke.
Reading: Bond; Gunter, McShane, Ferdinand, Obita; Williams, Norwood, Quinn, Robson-Kanu; Blackwood, Sa.
Subs: Al Habsi, Hector, Alex, Hurtado, Tshibola, McCleary, Cox.