Brentford have had to reshuffle their defence after injuries to James Tarkowkski and Maxime Colin.
Josh Clarke makes his first league start for the Bees at right-back while Yoann Barbet partners Harlee Dean in the centre.
Jota (ankle), Josh McEachran (foot), Marcos Tebar (hamstring), Andreas Bjelland and Scott Hogan (both knee) are all still unavailable.
Ryan Woods and Sergi Canos are among the substitutes, as is fellow signing Ryan Williams.
Preston make three changes, with Sheffield Wednesday loanee Marnick Vermijl, Alan Browne and Eoin Doyle coming in.
Former QPR loanee Will Keane is among the substitutes, while Preston’s Ealing-born former Wealdstone striker Jermaine Beckford is sidelined following knee surgery.
Subs not used: Bonham, O’Connell, Canos, Woods, Udumaga, Tebar, Williams.
Preston: Pickford; Vermijl, Clarke, Huntington, Cunningham; Browne, Kilkenny, Johnson; Doyle; May, Garner.
Subs not used: Kirkland, Woods, Wright, Welsh, Brownhill, Humphrey, Keane.