Ian Holloway says Jordan Cousins has suffered a torn hamstring and that Grant Hall’s tendonitis is an “ongoing problem”.
Both players have missed QPR’s recent friendlies and Cousins, who missed most of last season, appears to be facing another long spell on the sidelines.
Cousins was troubled by a hamstring problem following his move from Charlton last summer and missed the second half of the season because of a thigh injury.
Hall missed the final matches of the campaign and is still struggling ahead of the new season.
Rangers manager Holloway said: “Hally is going to be an ongoing problem – and you only have to look at our stats last season when we didn’t have him. I have to be patient with him.
“Jordan was doing ever so well in pre-season, he played over in Germany and now he’s gone and torn his hamstring. There’s a tear in his hamstring.”
Jake Bidwell missed Rangers’ friendly against Bournemouth at Loftus Road after going down with a stomach bug.
Joel Lynch started the game despite being affected by the same illness but was substituted at half-time.
“Lynchy did very well to play and Bidwell also had it. Bidwell was fantastic in training yesterday and then ill overnight,” Holloway explained.