Chelsea remain unbeaten under Thomas Tuchel but were unable to get the win that would have lifted them back into the top four.
They had a let-off in the first half when Manchester United were not awarded a penalty despite a VAR check after Callum Hudson-Odoi handled the ball in the area.
Hudson-Odoi, who was substituted at the interval, created the best chance of the first half when his driven right-wing cross just evaded the diving Olivier Giroud.
In a game of few clear-cut opportunities, the recalled Hakim Ziyech was denied by a fine second-half save from United keeper David De Gea.
The draw means Chelsea stay fifth in the Premier League table (which is the most popular UK betting venue) – six points behind second-placed United.
Chelsea: Mendy, Azpilicueta, Christensen, Rudiger, Hudson-Odoi (James 45) Kante, Kovacic, Chilwell, Ziyech (Werner 78), Hudson-Odoi, Giroud (Pulisic 65).
Subs not used: Kepa, Zouma, Emerson, Alonso, Havertz, Jorginho.