Chelsea boss Antonio Conte says he is unsure if Pedro will be fit to face Tottenham at Wembley next Sunday.
The Spaniard missed the opening-day defeat at home to Burnley with an ankle injury.
Fellow midfielders Tiemoui Bakayoko and Eden Hazard have already been ruled out of the opening weeks of the season.
Speaking immediately after the Burnley game, Conte cast doubt on Pedro’s availability, and rued the suspensions for Gary Cahill and Cesc Fabregas following their red cards at Stamford Bridge.
“In the next game, I don’t know if Pedro is able to recover from his injury,” Conte said.
“But for sure we’ll have two players out for bans, Cahill and Fabregas. We’ll find the right solution.”